The burger at the "Heart Attack Grill" restaurant is stacked with four beef patties, cheese, onions, tomatoes and fried bacon, and weighs in at only 8 000 calories, more than three times what the human body needs in one day.
Patrons who have no appetite for the "quadruple bypass burger" can opt for the "triple" or "double-bypass".
"It's not good for one's health but it's only a joke," John Basso, who opened the restaurant 10 months ago, told AFP.
Customers who have room for more can also order French fries "fried in pure lard" and can purchase cigarettes off the menu. As a courtesy, the restaurant offers its "best customers" a wheelchair service to their cars by waitresses dressed in slinky nurses' outfits.
The idea, however, has not gone down well with the Arizona State Board of Nursing which has expressed concern that some patrons may confuse the waitresses with real nurses.
To avoid any confusion, Basso has posted a long message on his restaurant website saying that his employees in no way are medical professionals.
He said his ultimate goal is to open a restaurant in France.
"I am dreaming of opening a restaurant in Paris," he said.